Formulation and evaluation of ibuprofen pulsin cap technique for controlled release

Oral controlled drug delivery systems represent the most popular form of controlled drug delivery systems for the advantages of oral route of drug administration. In certain conditions conventional drug release pattern is not suitable like Diabetes mellitus, Asthma, cardiovascular diseases Arthritis, Peptic ulcer etc. In such conditions pulsatile drug delivery system is used in which release drug on programmed pattern especially at appropriate time and at appropriate site of action. In PDDS a pulse is designed that a complete and rapid drug release is achieved after the lag time so as to match body’s circadian rhythms with the release of drug which increases the efficacy and safety of drugs by proportioning their peak plasma concentrations during the 24 hours in synchrony with biological rhythm. In this present study an attempt was made to formulate and evaluate ibuprofen as pulsing cap technique. The prepared capsules were evaluated for uniformity of weight, drug content and in vitro release. Promising results indicated the usefulness of thepulsin cap technique for controlled release of ibuprofen.